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Meanwhile, the mechanical ball-milling method can be applied in industrial production and provides a possible route for industrial applications of cocrystal explosives. In 2011, Bolton and Matzger successfully prepared CL-20/TNT cocrystal explosives and reported single-crystal data.
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The multi-component systems wherein one component is essentially the Active Pharmaceutical Ingredient and another may be either one more drug or coformer are termed as pharmaceutical cocrystal. Cocrystal is a novel, promising, and emerging approach to encountering such problems and improving the performance of …
The ball milling was performed using a jingxin JX-2013 ball miller for 2 h. The mixture was dried in a vacuum oven at room temperature for 12 h to render the cocrystal UQ-NC as a white powder.
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The implemented cocrystal screening procedure tested six coformers (all considered safe for human administration) added according to a drug:coformer ratio of 1:1 and 1:2 and seven solvents with different polarity. The screening method chosen was based on slurry cocrystallization performed by sonication (ultrasound assisted) in a 96-well plate.
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Guidelines from regulatory authorities (USFDA, EMA) regarding pharmaceutical cocrystals testify the established role of pharmaceutical cocrystals in the development of better candidates with improved characteristics. Still, this method has not become a routine method for the production of pharmaceuticals.
In this study, the cocrystal of PRX with succinic acid (SA), saccha-rin (Sac) and benzoic acid (BA) were prepared by mechanical ball milling. It was characterized by particle size analysis, scanning electron microscopy (SEM), differential scanning calorimetry (DSC), X-ray diffraction (XRPD), and infrared spectroscopy (FTIR).
The cocrystal ASC was prepared also by Liquid Assisted Grinding (LAG). ( )-catechin (50 mg, 0.172 mmol) and L-( )-ascorbic acid (30.3 þ þ mg, 0.172 mmol) were grinded in an agate ball miller for ...
A novel strategy for pharmaceutical cocrystals preparation without knowledge of the stoichiometric ratio based on the TPD was established and MYR cocrystals were successfully prepared. The present study provides a systematic approach for pharmaceutical cocrystal generation, which benefits the develo …
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The more stable the crystalline forms are, the more ubiquinol reaches the intestine. The enhanced stability of the cocrystal may be one reason for its increased bioavailability. The second step is the dissolution of ubiquinol, and the higher solubility of the cocrystal is another factor improving absorption.
The cocrystal operating range is the best tool to create cocrystals from the solution. This range can be found using eutectic points from the solution containing a cocrystal mixture and conformer. This range is explained by the ternary phase diagram ( Steed, 2013; Holaň et al., 2014 ), and it also explains the stability.
Lynda Miller Obituary. Lynda Ball Miller, 62 of Harlan, was born on September 27, 1954 in Cumberland, KY and entered Heaven on Saturday,January 7, 2017. Lynda was formerly employed at a Clinical Research Company as a Psychiatric RN. Her parents, Darnell and Jewell Johnson Ball and her husband, Jim Bob Miller, precede her …
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An overview of recent COSMO‐RS developments that are of interest for drug development is given and contains several new application examples for solubility prediction and solvate/cocrystal screening. The fact that novel drug candidates are becoming increasingly insoluble is a major problem of current drug development. Computational …
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The cocrystal ASC was prepared also by Liquid Assisted Grinding (LAG). (+)-catechin (50 mg, 0.172 mmol) and L- (+)-ascorbic acid (30.3 mg, 0.172 mmol) were grinded in an agate ball miller for 3 h in the presence of a small amount of ethanol (20 μL).
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Here, the compounds were ground in the ball mill for 25 min and x-ray characterization determined cocrystallization had taken place, indicating that the ball milling process to be a fast and successful approach for cocrystal synthesis.
Furthermore, several cocrystal preparation methods were required in order to isolate all of the crystal forms that were identified during the study, confirming the need for a multi-technique approach when …
Solution cocrystallization is a solvent-based approach that utilizes several single-component crystallization concepts as well as equipment for generating cocrystals. Solution-based techniques can produce cocrystals with reasonable control on purity, size distribution, morphology, and polymorphic form.