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In another study, using curcumin as a delivery vehicle loaded into Poly (caprolactone) (PCL) nanofibers used in topical wound-healing applications, they showed good biocompatibility and cyto-protective activity for human fibroblast cells and improved wound reduction (Merrell et al., 2009). Polycaprolactone (PCL) is a hydrophobic, semi ...
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When the drug-carrying nanoparticles are blended into a substrate of gelatin nanofibers, the gelatin part can mimic the extracellular matrix, trap the silica nanoparticles containing AgNPs and DOX in their polymer network, and release them into the environment. The PCL mat gives strength to the structure and stabilizes the gelatin part.
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The FDA-approved biopolymer poly (ϵ-caprolactone) (PCL) possesses high elasticity, and has been applied in biomedical applications extensively [13]. Silica is known as an essential component in bone tissue development, and it has been reported to promote osteoblast cell activity and to upregulate related gene expression [14], [15], [16].
The incorporation of osteogenic silica content into PCL matrix and the resulting well interconnected porous structure of the scaffolds demonstrated a remarkable increase of cell proliferation as evidenced by culture study.
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The ability to incorporate silica xerogels into the PCL hollow microspheres was examined by scanning electron microscopy. These PCL hollow porous microspheres have potential applications in the local delivery of proteins and drugs.
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Request PDF | Mesoporous silica incorporated PCL/Curcumin nanofiber for wound healing application | Electrospinning, a recent fast-emerging technique highly applicable in the production of ...
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